Figure 1.

Total BMC at the proximal, middle and distal parts of the femoral neck measured by pQCT densitometry. Effects of alendronate (ALN), calcitriol (VitD), and combined alendronate and calcitriol treatments (ALN+VitD) on the pQCT densitometric parameters of total BMC at the 3 parts of the femoral neck in OVX rats after 12 weeks of treatment are shown. The data are presented as mean ± SD (n = 6 per group). ^### P < 0.001 as compared with corresponding values in saline-treated OVX (unpaired t-test). * P < 0.05, ** P < 0.01, *** P < 0.001 as compared with corresponding values in saline-treated OVX (Tukey's multiple comparison test). Total BMC at the 3 parts of the femoral neck was significantly lower in the saline-treated OVX compared with the sham group. Alendronate treatment, with or without calcitriol, induced a significant improvement in all total BMC.